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6 B Vitamins Crucial to Adrenal Function


January 23, 2019 | Published by

It’s easy to forget about the effect adrenal fatigue has on your body’s consumption of nutrients, especially the B vitamins. When you’re stressed, the metabolism of cells speeds up and you burn through a lot more of the nutrients you normally need. By the time you are experiencing adrenal fatigue, your cells have used much of your body’s stored nutrients and are in critical need of new supplies to continue to function.

Here are 6 B vitamins that are essential for adrenal gland function and your body’s stress response. If you’re experiencing adrenal fatigue or chronic stress, it’s a good idea to add these to your supplement program.

Niacin (Vitamin B3)

Niacin, in addition to pantothenic acid, is one of the most important of the B vitamins to the adrenal cascade. Large amounts of niacin are necessary to form the molecular structure of certain niacin dependent coenzymes critical for several steps in this cascade. Therefore, a B complex that is high in niacin is important in facilitating some of the crucial enzymatic reactions that take place during the adrenal cascade. Our recommended daily amount of thiamine for adrenal support is 25-50 mg.

Thiamine (Vitamin B1)

Thiamine plays a central role in the release of energy from carbohydrates. It is involved in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) production, as well as nerve function. Our recommended daily amount of thiamine for adrenal support is 15-25 mg.

Riboflavin (Vitamin B2)

Riboflavin is involved in the release of energy in the electron transport chain, the citric acid cycle, as well as the breaking down of fatty acids. When vitamin B2 is provided as both riboflavin HCL and riboflavin-5’-phosphate, you get an immediate effect from the active HCL form which does not need to be broken down in your body.

The same goes for vitamin B6 when it is provided as both pyridoxine HCL and pyridoxine-5’-phosphate. This dual action means that the supply of these B vitamins lasts longer.

Our recommended daily amount of riboflavin for adrenal support is 15-25 mg.

Vitamin B6

The active form of pyridoxal-5’-phosphate (PLP) serves as a cofactor in many enzyme reactions, mainly in amino acid metabolism and biosynthesis of neurotransmitters. Vitamin B6 is also a co-factor in several of the enzymatic pathways in the adrenal cascade.

A small percentage of the population has difficulty metabolizing the regular vitamin B6 supplement (pyridoxine HCL) and as a result requires a P5P vitamin B6 supplement to fully activate these enzymatic pathways.

Our recommended daily amount of B6 for adrenal support is 90-150 mg.

Folate (Vitamin B9)

Folate acts as a co-enzyme in the form of tetrahydrofolate (TFH), which is involved in the transfer of single-carbon units in the metabolism of nucleic acids and amino acids. THF is involved in pyrimidine nucleotide synthesis, so it is needed for normal cell division, especially during pregnancy and infancy, which are times of rapid growth.

Our recommended daily amount of folate for adrenal support is 600-1000 mcg.

Pantothenic Acid (Vitamin B5)

Pantothenic acid is an essential contributor to energy production part of the adrenal cascade. Pantothenic acid is converted into acetyl CoA, a substance critical to the conversion of glucose into energy.

This B vitamin is present in all cells but in higher quantities in the adrenals because so much energy is needed to produce the adrenal hormones. The combination of pantothenic acid, magnesium, vitamin E and vitamin C increases energy production and takes much of the fatigue out of the adrenals without over-stimulating them.

Our recommended daily amount of pantothenic acid for adrenal support is 700-1200 mg.


Supplements designed especially for adrenal fatigue can play an important role in nourishing, supporting and strengthening your adrenals and the other glands and biochemical pathways involved in the stress response.

When properly formulated, these supplements can fortify the tissue structure of the adrenals, facilitate healthy adrenal function, support production of appropriate levels of adrenal hormones, and promote effective biochemical communication among the glands that interact to respond to stress and maintain homeostatic balance.


Vitamin B Complex. Navrachana University.

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