Mon-Fri 7am to 4:30pm (MST)   800-357-5027 or 520-748-0388

Adrenal Fatigue and the HPA Axis


June 12, 2019 | Published by

In last week’s blog we looked at the HPA axis, helping us further understand its function within the body. Today we’re going to dive a little deeper and explore how the HPA axis relates to stress and, more specifically, adrenal fatigue.

The amount of cortisol circulating at any moment is regulated by a complex interaction between the hypothalamus, pituitary, and adrenal glands. This regulatory trio is referred to as the HPA Axis and operates through a negative feedback system.

Cortisol, often referred to as the stress hormone, is not secreted uniformly throughout the day, but rather follows a diurnal pattern with the highest levels secreted at approximately 8:00 AM and the lowest between midnight and 4:00 AM. It is the rising cortisol level that helps us wake up in the morning.

After its peak at approximately 8:00 AM, cortisol downtrends through the rest of the day, often with a small dip in the afternoon between 3:00 and 5:00 PM. This dip is not a nice smooth curve, but rather filled with episodic spikes that generally fit into an increasing and decreasing pattern throughout the day and evening. Eating something, even a little snack, causes a small burst in cortisol.



In people with adrenal fatigue, this daily cycle of cortisol secretion may be irregular. Just as there are several long-term patterns of adrenal fatigue, there are circadian variations in adrenal fatigue as well. Some people with adrenal fatigue have an overall low pattern of cortisol secretion with circulating cortisol levels lower than normal at every point of the cycle.

Others spike to the normal level at 8:00 AM, but by 10:00 AM their cortisol levels have fallen below normal. Some exhibit the normal pattern and levels through most of the cycle but have a severe drop between 3:00 and 5:00 PM. Others fluctuate throughout the day and can even vary from day to day, making their cortisol levels unpredictable.

Whether these variations are a function of their overall stress level, adrenal health, food or environmental sensitivities, or other factors, it is important to be aware that in some people cortisol levels are very erratic during a 24-hour period. These people may go through part of their day with elevated cortisol levels, part of the day with low levels and part with normal levels.

An intimate association between stress and cortisol is manifested in several ways. No matter what the source of stress, most challenges to homeostasis stimulate the HPA axis, resulting in increased secretion of cortisol. As stress increases, progressively higher levels of cortisol are required. When these higher levels of cortisol cannot be produced, as in adrenal fatigue, the person cannot fully or appropriately respond to stress.

Even at normal levels, cortisol serves the very important function of priming the different mechanisms of your body so they can respond when called into action. During stress, cortisol must simultaneously mobilize fats and proteins for a back-up supply of glucose, as well as modify immune reactions, heartbeat, blood pressure, brain alertness and nervous system responsiveness.

Without cortisol, these mechanisms cannot react adequately to a significant stress. When cortisol levels cannot rise in response to these needs, maintaining your body under stress is nearly impossible. The more extreme the difference between the level of stress and the lack of cortisol, the more significant the consequences.

Cortisol is so important that when the HPA axis cannot increase cortisol activity in response to stress, these unrestrained mechanisms overshoot and can even damage your body. Thankfully, adrenal fatigue does not have to be a lifelong struggle. Eating properly (link), practicing a modest exercise routine (link), and supplementing your diet with the nutrients your adrenal glands need to stay optimal (link) are just a few ways to live a healthier life not controlled by stress.



Wilson, J. Adrenal Fatigue The 21st Century Stress Syndrome.

Tags: , , , , ,

Categorised in:

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.